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A number of genetic and environmental factors have been implicated in the etiology of rheumatoid arthritis (RA). The only well-established environmental risk factor is tobacco smoking, which has been shown in a number of studies to be associated with increased RA risk [ 1 – 4 ]. Associations between RA and factors such as diet [ 5 – 7 ], coffee intake [ 8 – 10 ], alcohol [ 11 – 13 ], and body mass index [ 12 – 14 ] have also been studied, but the evidence to suggest a causal role of these factors is inconclusive. A widespread theory is that one or more infectious agents might act as initiator in the pathogenesis of RA by having antigens similar to host antigens, a mechanism referred to as molecular mimicry [ 15 ], but the evidence in favor of any particular microbe is weak. Because RA is approximately three times as common in women as in men, sex hormones and reproductive factors have been suggested as potentially involved in the etiology [ 16 – 18 ]. Furthermore, a sexually transmitted agent with a higher male-to-female than female-to-male transmission rate might theoretically explain the female predominance in RA, but only few studies have examined sexual behavior and venereal diseases as possible risk factors [ 19 , 20 ].
One possible explanation for conflicting results in etiologic studies might be that risk factors differ between subtypes of RA. It was recently demonstrated that smoking is selectively associated with rheumatoid factor (RF)-positive RA [ 21 ] or with RA positive for anti-cyclic citrullinated peptide (CCP) antibodies [ 22 , 23 ]. Also, coffee consumption has been found to be selectively associated with RF-positive RA, although the association diminished considerably after adjustment for tobacco smoking [ 9 ]. Further supporting the existence of etiologically distinct subtypes of RA, recent case-control studies have shown that measures of low socioeconomic status are predominantly associated with risk of RF-positive RA [ 24 , 25 ]. The aim of the present study was to evaluate both new and previously hypothesised non-genetic risk factors in serologically defined subgroups of anti-CCP-positive and anti-CCP-negative RA.
Materials and methods.
Patients with RA and controls.
The study was conducted as a frequency-matched case-control study. Patients with RA diagnosed within the previous 5 years were identified in rheumatology and internal medicine departments throughout Denmark, which has a predominantly Caucasian population of approximately 5.2 million inhabitants. To be included, patients had to be diagnosed with RA between ages 18 and 65 years and fulfill the American College of Rheumatology (ACR) 1987 classification criteria for RA [ 26 ] between August 1998 and July 2003. Information about date of diagnosis, defined as the date when the RA diagnosis was clinically confirmed by a rheumatologist, and cumulative fulfillment of the ACR 1987 classification criteria for RA was obtained from medical records by a rheumatologist at each department or by the project coordinator (MP) and a rheumatologist (MK) from the study team.
Controls who were frequency-matched by gender and birth year were randomly selected from the Danish population by means of the Civil Registration System, a national database that keeps track of all demographic changes in Denmark [ 27 ]. Using identical invitation letters to cases and controls, we aimed at a 1:1 case-control ratio for women and a 1:2 case-control ratio for men, but all invited subjects who agreed to participate were included. A higher number of controls per case among men was chosen in order to enhance statistical power in analyses of RA in men.
The questionnaire was tested in a pilot experiment comprising 50 patients with RA and 50 controls whose data are not included in this report. Three trained female medical students carried out all interviews between September 2002 and February 2004. Bimonthly meetings were held to ensure that all interviews were conducted in a uniform manner. Interviews were conducted as computer-assisted telephone interviews, and answers were entered directly into a database. Logical tests were built into the program to keep data entry errors at a minimum. Each telephone interview took approximately half an hour and included questions about a wide range of exposure and confounder variables, including level of education, age at menarche, parity, spontaneous abortions, breastfeeding, age at menopause, use of oral contraceptive pills and hormone replacement therapy, marital status, lifetime number of sexual partners of opposite sex, age at first sexual intercourse, lifetime number of anal-intercourse partners of opposite sex, lifetime number of same-sex sexual partners (male study participants only), lifetime number of prostitute visits (male study participants only), histories of venereal diseases (including chlamydia, genital herpes, acuminate condylomas, gonorrhea, and syphilis), smoker status, pack-years smoked (one pack-year equivalent to 20 cigarettes per day for 1 year with one cigarette equivalent to 1 g, one cheroot to 3 g, and one cigar to 4 g of tobacco), coffee, alcohol, and wine consumption 10 years before interview, frequency of fish intake as a hot meal or on bread (at least once a week, 1–3 times a month, less than once a month) 10 years before interview, intake of fish oil (ever/never), vegetarian diet (ever/never), body mass index at age 20 years and 10 years before interview, level of physical activity at work and during leisure time 10 years before interview, pets in childhood and in adulthood, histories of mononucleosis, hay fever, atopic dermatitis, asthma before age 45 years, stomach or duodenal ulcer, heavy diarrhea of at least 4 days’ duration, type I diabetes, thyroid disease, periodontal disease, urinary tract infection, cancer, blood transfusion, tonsillectomy, adenoidectomy, appendectomy, splenectomy, and schizophrenia among first-degree relatives.

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The charity said its investigation exposed the “disturbing prevalence” of prostitution across the capital.
The charity surveyed more than 900 brothels and found many offered high-risk “services” such as unprotected anal sex for just ?10 extra. Kissing is also available for an extra ?10, much cheaper than in previous years.
Researchers posed as potential “punters” and phoned 921 brothels which advertised in local newspapers, and discovered that 77 different ethnicities of women were being offered for sex.
Many came from well-known trafficking hotspots such as eastern Europe and south-east Asia.
Co-author Helen Atkins said: “This research shows the disturbing prevalence of the sex industry in every corner of London – fuelled by the demand for prostitution services.
“Multi-media misrepresentations of commercial sex as a glamorous, easy and fun career choice for girls and women further contribute to the ubiquity of London’s brothel industry.
“However, for most women involved in prostitution, the reality is a cycle of violence and coercion, perpetuated by poverty and inequality.”
The average price for full sex was just under ?62.
Researchers were told 95% of the surveyed brothels were in a residential location with a “discreet appearance”.
One brothel told researchers they offered first-time customers a 50% off voucher for their next visit.
Independent escorts are a rare and intriguing breed exceptional in every way imaginable. There are a variety of personalities and physiques from whom you can select when it comes to getting acquainted with an independent escort. Many of these ladies are international, cultured, college educated and speak multiple languages. What separates them from the rest is that they have mastered the art of sensual entertainment. There is no woman more skilled in modern, intimate interaction than today’s independent escort. If you are a woman reading these words and are curious, chances are you are well on your way to becoming an independent escort.
Just what is an escort?
She’s not necessarily a stereotype. She may not conform to a myth or a dress size. She may be the girl next door, an executive assistant at the office or a school teacher. Today’s independent escort is modern because she has the freedom to define who she wants to be. She has many interests and has a vivacious appetite for cultivating exhilarating moments with her suitors. She is extremely sensual and harbors a deep understanding of the needs and desires of men. She is usually a powerhouse of a woman whether subtle or overt and we can usually learn something from her.
Being an escort is a real business.
Being a secretary is a job. Being a postal worker is a job and both make a living. Being an independent escort is not a job. It’s a business with abilities to make money limited only by your ambition. Essentially, an escort is self-employed and determines her own hours. An escort who considers herself a professional entertainer is one who is respected and sought after by her clients. Her work is multi-faceted and metropolitan and these are things upon which she thrives.
Learning about your clients.
One of the most important, fundamental principles to learn about being an independent escort is that you are paid for your time. Dispel the common myth that a client has total control over your time together. Most often, it is the escort who sets the pace, who is looked toward by her client to determine the beat and flavor of their experience together. Many clients seek companionship in the form of a girlfriend experience, desire intimacy, engaging conversation and affection. Above all, the most important aspect of being an escort is to listen to your client from the moment you make contact. That is essentially your duty.
How to become a top escort.
As an independent escort, you don’t necessarily have to be in business for 5 years (or more) to be high in demand. At City Girls, we know plenty of ladies who do not have such tenure and rank among the top in their respective cities on websites such as TER and others. Why is that? It is because they have mastered their skills as an escort: they know how to present and carry themselves; they are good listeners; they take very good care of themselves physically and mentally; they have honed their sensual skills; they are good conversationalists; they are selective and they truly enjoy companionship with worthy suitors. These same women are not afraid to place a fair premium on their relationships.
Where to do business as an independent escort.
Ever heard the adage, “Don’t wait for the business to come to you. Go out and get it.”? That’s kind of the way it is for many successful, independent escorts nowadays. While some companions may be fulfilled running their businesses in their base cities, touring is the progressive answer for many. No matter where you live, business may not always be booming in your area. Just the notion of that risk of inconsistency in work should lead you to at considering touring as an integral part of your business. What if there is a world-wide convention of businessmen in a neighboring state? What if your type of client prevails in a city just a 2-hour flight away? Touring can be tricky because there’s so much research, planning and thinking involved. While there are ladies who tour and travel exclusively as independent escorts, City Girls has it down to a science and takes care of all of the details for you so that you can do what you do best – have fun entertaining and being an independent at the same time!

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Come on who here can say they haven’t gotten so high that they thought cutting off your passed out roommates head wasn’t worth a laugh?
Lol I’ve only gotten as far as stuffing marshmallows in my sleeping husband’s socks. I was bored.
Anyone got good stories?
One time we held my friend’s brother down and squeezed mustard up his ass. It was spicy mustard too so you know that shit burned his insides like a mofo, most of us got a good laugh….ahhh good times. Haa just joking(or am I??)lol.
Lol, lol, fuck @Joedirt that was too funny man, as that poor fuckers arsehole must have burned like a Virgins Cunt on prom night, me thinks.
next time use grey poupon,its much classier!
Horseradish would be nice too.
I have a friend who super glued her ex-husband’s penis to his thigh. He had to take a trip to the hospital to get it sorted out. She caught him watching porno and jerking off in the living room with the kids asleep in their room. Rule was only in the locked bedroom where the kids could not accidentally see it. He was drunk and passed out with his cock in his hand. She taught him a lesson.
I was damn hellion did all sorts of crazy shit. way too young to be clowning around as I was. I did shit I am not proud of, lame stuff no real bodily injury , super soaked some prostitutes. set massive field on fire, accidentally. broke some stuff , tore wallpaper off hotel room to reveal lovely pattern beneath. but I finished the peel, didn’t leave it all jacked up. but hell it was all done with crazy pack of friends and alcohol and weed and maybe bit of acid , shit was fun but all I did on that was stare at stuff and drink a lot of beer and weed,shit just disappears on that. notgoing to lie if I ever met up with my onks id laugh my ass off reliving crazy shit we did. but was rather harmless and never got heavy never stole anything but Pabst beer from parents and hell no was no heroin or meth I haven’t a clue what ecstasy is and I had to google spice. what a shit drug. and what a shitty end for headless fella regardless what brought them together.
“Spice” the nastiest high I’ve ever experienced.
I took one single big ass hit off of a one footer and before I could exhale or as I was exhaling I had a religious experience unlike anything I’ve gone through.
I truly felt like if I was gonna die.
My hearth was pumping/beating so rapidly I thought I was gonna have a hearth attack and I remember walking a bit all dazed out and felt the need to grab/hold on to a fence cause it felt like I could collapse. My corporal temperature went higher than my high and had to grab the hose and let water just pour in my head to cool me down for like 20 fucking minutes.
“Spice” ain’t no joke if you ever want or consider using it be sure that that shit is a trippy high and take it slow until you feel what it does to your body.
I’ve known people who smoke spice like tobacco and they don’t get all crazy and shit.
In California where I’m from you can walk in to most every smoke shop and buy a $10, $20 bag of spice with no problem. Not even ID required if you look +18yrs.
I’m rolling a blunt as I Swype and I’m feeling tempted to…. Nevermind, I was thinking of spicing shit up a little bit but I’m cool on that.
Who knows if today’s spice is the same as the spice 3-4 yrs ago. I’m gonna pass on this one…
I’ve had two horrible experiences, once with Salvia, the other with Mr. Nice Guy.
With Salvia, I ended up screaming until I lost my voice because of the horrible hallucinations, backing myself into the bedroom closet.
The Mr. Nice Guy gravity bong hit, rocked my whole comprehension of the universe.. Then after believing that I was dying from a heart attack, I searched for a sharp object to kill myself with, fortunately it was a jigsaw, and they wrestled it from me before reaching the outlet.
Then, I jump up like a enraged maniac, bolt for the door, scream like a banshee, kick over a crotch rocket, and bolted for the woods, becoming Rambo, tearing pieces of my shirt off to throw ‘them’ off my trail, rubbing dirt and leaves on me to blend.. I showed up four miles away after coming back to my senses. Completely not fucking cool. I will never be tempted to try that synthetic kibble again.
@joedirt9 omg! That’s awful! Hilarious but awful lol.
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37 – Writing the low down, the high up and the sideways.
‘Write me the low down, the high up and the sideways,’ Kay Swift would urge her best friend when she was stranded on the ranch in Oregon, mucking out stables layered in clothes and trying to live without running water. Recovering from the frantic pace and emotional battles of NYC, she still longed to hear all the news.
It may seem that I’m going off topic here, delving into the friendship between Mary and Kay, but it’s essential context for setting up the arrival of Aideen in New York and the adventures that are to come …
In an audio file on the Columbia University website, you can listen to Mary Woodward Reinhardt Lasker ( Lamb to Kay Swift) describe her life in New York in the 1930s and read the lengthy transcript of that interview. After a few minutes, I found myself turning off the husky voice of the sixty-something-year-old. Reading the transcript, it’s so easy to hear her young, vibrant self.

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